SRP4580

BMP-14 (GDF-5/CDMP-1) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• 동의어(들): BMP-14/ CDMP-1, Cartilage derived morphogenetic protein-1, GDF-5, bone morphogenetic protein 14
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥98% (HPLC); ≥98% (SDS-PAGE)
• 양식: lyophilized
• 효능: 0.5-4 μg ED₅₀
• 분자량: ~27 kDa
• 포장: pkg of 50 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 불순물: endotoxin, tested
• NCBI 수납 번호: X80915
• UniProt 수납 번호: P43026
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... GDF5(8200)

설명

일반 설명

The gene BMP-14 (bone morphogenetic protein 14) is mapped to human chromosome 20q11.22. It belongs to the bone morphogenetic protein family. Recombinant human BMP-14 is a 27kDa homodimeric protein consisting of two 120 amino acid polypeptide chains.

생화학적/생리학적 작용

BMP-14 (bone morphogenetic protein 14) is involved in enhancing proliferations of osteoblasts, periosteum cells and connective tissue fibroblasts. It also promotes endochondral bone growth, proper development of limb skeletons and joints, and odontogenesis. It interacts with BMP type II receptor (BMPR-II) and might be involved in bone morphogenesis. Mutations in the BMP-14 gene are associated with brachydactyly type C, intervertebral disc degeneration, acromesomelic dysplasia Grebe type and osteoarthritis.

물리적 형태

Lyophilized from 10 mM Sodium Citrate, pH 3.5.

재구성

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable