SRP6323

Pentraxin 3 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• 동의어(들): PTX3, TNFAIP5, TSG-14
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥90% (SDS-PAGE)
• 양식: liquid
• 분자량: 44.4 kDa (401 aa, 18-381 aa + His Tag)
• 포장: pkg of 100 μg
• 농도: 1 mg/mL
• 불순물: <1 EU/μg endotoxin (LAL test)
• UniProt 수납 번호: P26022
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... PTX3(5806)

설명

일반 설명

Pentraxin 3 (PTX3) or tumor necrosis factor (TNF)-stimulated gene is the prototypic member of the long pentraxin family sharing the C-terminal domain with short pentraxins and containing a unique N-terminal domain. The gene encoding this protein is localized on human chromosome 3q25.32 and consists of 3 exons. Recombinant human Pentraxin 3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

생화학적/생리학적 작용

Pentraxin 3 (PTX3) is an acute phase protein produced and released at inflammatory sites by diverse cell types including monocytes/macrophages, endothelial cells, vascular smooth muscle cells, fibroblasts, and adipocytes. It plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. PTX3 particularly functions as a soluble pathogen recognition receptor and confers resistance against pathogens. Studies indicate that the protein removes apoptotic cells during immune responses. It associates with complement factor H, which is a complement regulator protein.

물리적 형태

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 1 mM DTT.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable