SRP8023

PARG human

recombinant, expressed in Sf21 cells, His tagged, >95% (SDS-PAGE)

• 동의어(들): FNDC5 (cleaved), Poly(ADP-ribose) glycohydrolase
• CAS Number: 9068-16-0
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in Sf21 cells
• 태그: His tagged
• 분석: >95% (SDS-PAGE)
• 양식: liquid
• 분자량: ~110 kDa by SDS-PAGE
• 포장: pkg of 2 μg
• 농도: ≥0.2 mg/mL
• 기술: cell based assay: suitable
• 색상: clear
• solubility: water: soluble
• UniProt 수납 번호: Q86W56
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... PARG(8505)

설명

일반 설명

Research area: Cell signaling

애플리케이션

PARG human has been used in the digestion of sciatic nerve sections, in co-immunoprecipitation, in in vitro glycohydrolase activity assay

생화학적/생리학적 작용

Poly(ADP-ribose) glycohydrolase(PARG) hydrolyzes poly(ADP-ribose) at glycosidic(1′′-2′′) linkage of ribose-ribose bond to produce free ADP-ribose. It is an endo- and exo-glycosidase. PARG plays arole in DNA repair and replication. Inhibited or depleted PARG in cells aremore prone to DNA-damaging agents. PARG also averts the accumulation of PAR inthe cytoplasm and parthanatos, a caspase-independent PAR-mediated type of celldeath.

물리적 형태

Solution in 50 mM TRIS-HCl, pH 7.5, containing 100 mM sodium chloride, 0.2% NP-40, 50 mM imidazole and 10% glycerol.

기타 정보

Human PARG is fused to a His-tag.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360D
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable