SRP8040

LAG-3 (human): FC (human)

recombinant, expressed in CHO cells, >99% (SDS-PAGE)

• 동의어(들): FDC Protein, Lymphocyte activation gene-3, PC cell-derived growth factor
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in CHO cells
• 분석: >99% (SDS-PAGE)
• 양식: liquid
• 분자량: ~80 kDa by SDS-PAGE
• 포장: pkg of 50 μg
• 농도: ≥0.2 mg/mL
• 불순물: <0.1 EU/μg endotoxin, tested
• 색상: clear
• UniProt 수납 번호: P18627
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... LAG3(3902)

설명

일반 설명

LAG3 (lymphocyte activation gene 3) is an inhibitory CD4 (cluster of differentiation)-related molecule, and is expressed by activated CD4⁺ and CD8⁺ T cells.

생화학적/생리학적 작용

LAG3 (lymphocyte activation gene 3) is a negative regulator of T-cell proliferation where it suppresses T-cell receptor (TCR)-mediated calcium fluxes and modulates the memory T-cell pool size. It is a CD4 (cluster of differentiation) homolog that functions as a ligand for MHC (major histocompatibility complex) II. Membrane expression of LAG3 modulates the suppressive function of Tregs (T-regulatory) both in vivo and in vitro. HIV-1 (human immunodeficiency virus) infection results in significant increase in LAG3 peripheral blood and lymph node expression, which is exhibited on both CD4⁺ and CD8⁺ T cells, and this is linked with disease progression. In melanoma, this protein is responsible for TLR (Toll-like receptor)-independent activation of plasmacytoid dendritic cells (pDCs) at tumor sites, which is partially implicated in driving an immune-suppressive environment.

물리적 형태

Solution in PBS.

기타 정보

The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable