T0642

Tubercidin

from Streptomyces tubercidicus, ~95%

• 동의어(들): 7-Deazaadenosine
• 실험식(Hill 표기법): C₁₁H₁₄N₄O₄
• CAS Number: 69-33-0
• Molecular Weight: 266.25
• Beilstein: 38498
• EC Number: 200-703-4
• MDL number: MFCD00056012
• UNSPSC 코드: 51102829
• PubChem Substance ID: 24899902
• NACRES: NA.85

속성

• 생물학적 소스: Streptomyces tubercidicus
• Quality Level: 200
• 분석: ~95%
• 양식: powder
• 색상: off-white
• 항생제 활성 스펙트럼: fungi; parasites; viruses
• 동작 모드: DNA synthesis | interferes
• SMILES string: O[C@H]1[C@@H](O)[C@H](N2C=CC3=C2N=CN=C3N)O[C@@H]1CO
• InChI: 1S/C11H14N4O4/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(18)7(17)6(3-16)19-11/h1-2,4,6-8,11,16-18H,3H2,(H2,12,13,14)/t6-,7-,8-,11-/m1/s1
• InChI key: HDZZVAMISRMYHH-KCGFPETGSA-N
• 유전자 정보: rat ... Adora1(29290)

설명

일반 설명

Chemical structure: nucleoside

애플리케이션

It is used to study tubercidin′s mechanism of toxicity, tubercidin resistance and is used as a selection agent. Tubercidin is used to study RNAi silencing. It is used to study the role of transmethylation in chemotaxis of eukaryotic cells.

생화학적/생리학적 작용

Toxic adenosine analog with antiviral, antitrypanosomal, and antifungal functions. Mode of action: Inhibits multiple metabolic processes, including RNA processing, nucleic acid synthesis, protein synthesis, and methylation of tRNA through intracellular incorporation into nucleic acids. Tubercidin acts as a plant antifungal, inhibits mammalian SAH hydrolase (SAHH), and blocks purine biosynthesis in Candida famata.

Tubercidin is a toxic adenosine analog with antiviral, antitrypanosomal, and antifungal functions. It inhibits multiple metabolic processes, including RNA processing, nucleic acid synthesis, protein synthesis, and methylation of tRNA through intracellular incorporation into nucleic acids. Tubercidin acts as a plant antifungal, inhibits mammalian SAH hydrolase (SAHH), and blocks purine biosynthesis in Candida famata. Tubercidin inhibits glycolysis in Trypanosoma brucei. Tubercidin inhibits both chemotaxis and chemotaxis-dependent cell streaming of Dictyostelium, and chemotaxis of neutrophils at concentrations that have little effect on cell viability.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300
• 예방조치 성명서: P264 - P301 + P310
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges