T151

(+)-Thalidomide

≥98% (HPLC), powder

• 동의어(들): R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• 실험식(Hill 표기법): C₁₃H₁₀N₂O₄
• CAS Number: 2614-06-4
• Molecular Weight: 258.23
• MDL number: MFCD00210220
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24899975
• NACRES: NA.77

속성

• ligand: thalidomide
• 분석: ≥98% (HPLC)
• 양식: powder
• 반응 적합성: reagent type: ligand
• 색상: white to beige
• solubility: DMSO: 15 mg/mL, clear
• 주관자: Celgene
• 저장 온도: room temp
• SMILES string: O=C1CC[C@@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
• InChI: 1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m1/s1
• InChI key: UEJJHQNACJXSKW-SECBINFHSA-N
• 유전자 정보: human ... LITAF(9516), TNF(7124) ; mouse ... Nos2(18126) ; rat ... Nos1(24598)

설명

애플리케이션

Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.

생화학적/생리학적 작용

(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.

특징 및 장점

This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

제조 메모

Thalidomide is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml. It is insoluble in ethanol and water.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H360
• 예방조치 성명서: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges