T4577

Terodiline hydrochloride

≥98% (HPLC), solid

• 동의어(들): Bicor, N-(1,1-Dimethylethyl)-alpha-methyl-gamma-phenylbenzenepropamine hydrochloride
• 실험식(Hill 표기법): C₂₀H₂₇N·HCl
• CAS Number: 7082-21-5
• Molecular Weight: 317.90
• MDL number: MFCD00941402
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826797
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: white to off-white
• solubility: DMSO: >20 mg/mL
• 저장 온도: −20°C
• SMILES string: Cl.CC(CC(c1ccccc1)c2ccccc2)NC(C)(C)C
• InChI: 1S/C20H27N.ClH/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,16,19,21H,15H2,1-4H3;1H
• InChI key: RNGHAJVBYQPLAZ-UHFFFAOYSA-N
• 유전자 정보: human ... CACNA1A(773), CACNA1B(774), CACNA1C(775), CACNA1D(776), CACNA1E(777), CACNA1F(778), CACNA1G(8913), CACNA1H(8912), CACNA1I(8911), CACNA1S(779), CACNA2D1(781), CACNA2D2(9254), CACNA2D3(55799), CACNA2D4(93589), CACNB1(782), CACNB2(783), CACNB3(784), CACNB4(785), CACNG1(786), CACNG2(10369), CACNG3(10368), CACNG4(27092), CACNG5(27091), CACNG6(59285), CACNG7(59284), CACNG8(59283), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

설명

생화학적/생리학적 작용

Terodiline hydrochloride is a non-selective calcium channel antagonist with anticholinergic and vasodilatory activity.

Terodiline is known to increase corrected QT interval (QTc) and decrease resting heart rate in elderly patients. Furthermore, terodiline hydrochloride has been linked to cardiac arrhythmias¹.

특징 및 장점

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

Terodiline hydrochloride is soluble in DMSO at a concentration that is greater than 20 mg/ml.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H319,H400
• 예방조치 성명서: P273 - P301 + P312 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves