T7154

Tyr-Ile-Gly-Ser-Arg

≥97% (HPLC)

• 동의어(들): Laminin Fragment 929-933
• 실험식(Hill 표기법): C₂₆H₄₂N₈O₈
• CAS Number: 110590-64-2
• Molecular Weight: 594.66
• MDL number: MFCD00076472
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24900419
• NACRES: NA.32

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: powder
• 기술: cell culture | mammalian: suitable
• solubility: H₂O: soluble 1 mg/mL, clear, colorless
• 저장 온도: −20°C
• SMILES string: CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1
• InChI key: MWOGMBZGFFZBMK-LJZWMIMPSA-N

설명

Amino Acid Sequence

Tyr-Ile-Gly-Ser-Arg

애플리케이션

Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.

생화학적/생리학적 작용

Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.

Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.

제조 메모

Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)