T8575

Anti-Tryptophan Hydroxylase Antibody

sheep polyclonal

• 동의어(들): Anti-TPH
• MDL number: MFCD00282500
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• Product Name: Anti-Tryptophan Hydroxylase antibody produced in sheep, affinity isolated antibody, buffered aqueous glycerol solution
• 생물학적 소스: sheep
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous glycerol solution
• 사용: sufficient for 10 blots
• 종 반응성: mammals, human
• 기술: western blot: 1:1,000 using human dorsal raphe nucleus
• UniProt 수납 번호: P17752
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... TPH1(7166) ; mouse ... Tph1(21990) ; rat ... Tph1(24848)

설명

일반 설명

The tryptophan hydroxylase 1 (TPH1) gene spanning 29kbp with 11 exons is mapped to human chromosome 11p15.3-p14. TPH1, is a 444 amino acid protein expressed in the gut, spleen, thymus and also in the pineal gland and the pituitary.

Tryptophan Hydroxylase (TPH) is a member of the aromatic amino acid hydroxylases (AAAH) family.

면역원

recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE.

애플리케이션

Anti-Tryptophan Hydroxylase antibody produced in sheep has been used in:

• immunocytochemistry
• immunohistochemistry
• immunofluorescence
• immunoperoxidase staining

생화학적/생리학적 작용

The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan, which is a precursor to the neurotransmitter serotonin. Variation in the gene expression affects prefrontal cortex activation during response inhibition. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders. The encoded protein plays a vital role in regulation of cardiovascular function.

물리적 형태

Solution in 150 mM NaCl, 10 mM HEPES, pH 7.5, 100 μg per mL BSA, and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)