T8904

Thiabendazole

≥99%, powder

• 동의어(들): 2-(4-Thiazolyl)benzimidazole
• 실험식(Hill 표기법): C₁₀H₇N₃S
• CAS Number: 148-79-8
• Molecular Weight: 201.25
• Beilstein: 611403
• EC Number: 205-725-8
• MDL number: MFCD00005587
• UNSPSC 코드: 51453501
• PubChem Substance ID: 24900571
• NACRES: NA.85

속성

• Quality Level: 200
• 분석: ≥99%
• 양식: powder
• 색상: white to off-white
• solubility: DMF: soluble 50 mg/mL
• 항생제 활성 스펙트럼: fungi; parasites
• 동작 모드: enzyme | inhibits
• SMILES string: c1ccc2[nH]c(nc2c1)-c3cscn3
• InChI: 1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
• InChI key: WJCNZQLZVWNLKY-UHFFFAOYSA-N
• 유전자 정보: human ... CYP2C9(1559)

설명

일반 설명

Chemical structure: imidazole

애플리케이션

Thiabendazole (TBZ) is a broad-spectrum antihelminthic and is used to treat parasitic infections in humans. It is used as an agricultural fungicide and as a food preservative. Thiabendazole has been used as a heavy metal chelating detoxification agent. It is used clinically to treat threadworm, cutaneous larva migrans, visceral larva migrans, and trichinosis.

생화학적/생리학적 작용

Thiabendazole inhibits anaerobic respiration at the level of mitochondrial helminth-specific enzyme. It acts as a quinol-fumarate reductase (QFR) inhibitor in ,C. jejuni and H. pylori, blocking quinol oxidation to quinone. Thiabendazole suppresses egg and larval production and may inhibit the subsequent development of eggs and larvae which are passed in feces. A proposed route of biotransformation of thiabendazole is the CYP1A2-catalyzed hydroxylation to 5-hydroxythiabendazole, which is metabolized to glucuronide and sulfate conjugates.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

안전성 정보

• 픽토그램: GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H410
• 예방조치 성명서: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves