U2508

Ubiquitin Carrier Protein H2 human

• MDL number: MFCD04041190
• UNSPSC 코드: 12352202
• NACRES: NA.56

속성

• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in E. coli (GST-tagged)
• 분석: >95% (SDS-PAGE)
• 양식: solution
• 분자량: ~14 kDa
• UniProt 수납 번호: P61088; P62256
• 응용 분야: cell analysis
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... UBE2H(7328), UBE2N(7334)

설명

생화학적/생리학적 작용

UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event.

UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event. TNF-α was shown to stimulate expression of UbcH2 in skeletal muscle cells by increasing binding of NFκ-B to the promoter region of UbcH2, inducing transcription.

물리적 형태

Solution in 50 mM HEPES, 50 mM NaCl, 10% glycerol, 1mM DTT, pH 7.8

기타 정보

manufactured for Sigma by Boston Biochem. Inc.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable