U4127

Urocortin human

≥85% (HPLC), powder

• 실험식(Hill 표기법): C₂₀₄H₃₃₇N₆₃O₆₄
• CAS Number: 176591-49-4
• Molecular Weight: 4696.24
• MDL number: MFCD00802621
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 분석: ≥85% (HPLC)
• 양식: powder
• 기술: ligand binding assay: suitable
• UniProt 수납 번호: P55089
• 저장 온도: −20°C
• 유전자 정보: human ... UCN(7349)

설명

Amino Acid Sequence

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

애플리케이션

Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.

생화학적/생리학적 작용

Binds to CRF receptor types 1, 2α, and 2β.

Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.

Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)