X4376

Xanthine Oxidase from bovine milk

lyophilized powder, 0.4-1.0 units/mg protein

• 동의어(들): XOD, Xanthine:oxygen oxidoreductase
• CAS Number: 9002-17-9
• EC 번호: 1.17.3.2.
• EC Number: 232-657-6
• MDL number: MFCD00082145
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 생물학적 소스: bovine milk
• Quality Level: 300
• 양식: lyophilized powder
• 특이 활성도: 0.4-1.0 units/mg protein
• 분자량: 283 kDa
• 구성: Protein, 10.0-25.0%
• 저장 온도: 2-8°C

설명

일반 설명

Formerly E.C. 1.1.3.22

애플리케이션

Xanthine Oxidase from bovine milk has been used as a source for superoxide generation. It has also been used as a model enzyme in the internally calibrated electrochemical continuous enzyme assay (ICECEA).

생화학적/생리학적 작용

The isoflavanoid genistein was shown to inhibit xanthine oxidase at concentrations between 0.1-4.0 μM and then activate xanthine oxidase at concentrations higher than 5 μM.

Xanthine Oxidase acts as a potential biomarker for oxidative stress. It is also implicated in tissue and vascular injuries such as liver damage, inflammatory diseases and chronic heart failure.

Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species.

단위 정의

One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.

물리적 형태

Contains 0.5% sodium salicylate.

분석 메모

Protein determined by biuret

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H334
• 예방조치 성명서: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)