Z0877

Zotepine

• 동의어(들): 2-[(8-chlorodibenzo[b,f]-thiepin-10-yl)oxy]-N,N-dimethylethanamine
• 실험식(Hill 표기법): C₁₈H₁₈ClNOS
• CAS Number: 26615-21-4
• Molecular Weight: 331.86
• MDL number: MFCD00868143
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329831602
• NACRES: NA.77

속성

• 분석: >98% (HPLC)
• Quality Level: 100
• 양식: powder
• 색상: white to off-white
• solubility: DMSO: ≥20 mg/mL
• 주관자: Astellas
• 저장 온도: room temp
• SMILES string: CN(C)CCOC1=Cc2ccccc2Sc3ccc(Cl)cc13
• InChI: 1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
• InChI key: HDOZVRUNCMBHFH-UHFFFAOYSA-N

설명

애플리케이션

Zotepine has been used as an anti-psychotic agent:

• in biophysical studies with serotonin 2A receptor (5-HT_2AR)
• to study its effects on the inhibition of human organic cation transporter 1 (hOCT1)
• to study its protective effects on the human embryonic kidney (HEK cells)

생화학적/생리학적 작용

Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT_2A/2C) receptors, and noradrenaline transporters. It shows therapeutic effects against schizophrenia and acute mania.

Zotepine is an atypical antipsychotic.

특징 및 장점

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Astellas. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H410
• 예방조치 성명서: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable