Z0878

Zaprinast

solid

• 동의어(들): 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
• 실험식(Hill 표기법): C₁₃H₁₃N₅O₂
• CAS Number: 37762-06-4
• Molecular Weight: 271.27
• EC Number: 253-655-1
• MDL number: MFCD00214073
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24278072
• NACRES: NA.77

속성

• 양식: solid
• Quality Level: 200
• 색상: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL; DMSO: 10 mg/mL; H₂O: insoluble
• SMILES string: CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2
• InChI: 1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
• InChI key: REZGGXNDEMKIQB-UHFFFAOYSA-N
• 유전자 정보: human ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144)

설명

애플리케이션

Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.

생화학적/생리학적 작용

Selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).

Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves