Z2626

Zaragozic acid A trisodium salt

from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor

• 동의어(들): L-694,599, Squalestatin
• 실험식(Hill 표기법): C₃₅H₄₃O₁₄Na₃
• CAS Number: 144541-82-2
• Molecular Weight: 756.68
• MDL number: MFCD03788025
• UNSPSC 코드: 12352106
• NACRES: NA.77

속성

• Product Name: Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial
• 생물학적 소스: microbial
• Quality Level: 200
• 분석: ≥95% (HPLC)
• 양식: lyophilized powder
• solubility: DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

애플리케이션

Zaragozic acid A trisodium salt has been used as:

• a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
• a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
• a cholesterol synthesis inhibitor in T cells

생화학적/생리학적 작용

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

법적 정보

Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)