122564

Mechlorethamine hydrochloride

98%

• Synonym(s): 2-Chloro-N-(2-chloroethyl)-N-methylethanamine, N-Methylbis(2-chloroethyl)amine hydrochloride, Bis(2-Chloroethyl)methylamine, Bis(2-chloroethyl)methylamine, MBA hydrochloride, NM, Nitrogen mustard
• Linear Formula: (ClCH₂CH₂)₂NCH₃·HCl
• CAS Number: 55-86-7
• Molecular Weight: 192.51
• EC Number: 200-246-0
• MDL number: MFCD00012517
• UNSPSC Code: 12352100
• PubChem Substance ID: 24847496
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 98%
• form: solid
• mp: 108-111 °C (lit.)
• solubility: H₂O: very soluble; alcohol: soluble
• functional group: amine; chloro
• SMILES string: Cl.CN(CCCl)CCCl
• InChI: 1S/C5H11Cl2N.ClH/c1-8(4-2-6)5-3-7;/h2-5H2,1H3;1H
• InChI key: QZIQJVCYUQZDIR-UHFFFAOYSA-N

Description

Application

Mechlorethamine hydrochloride was used in a fluorescence-based apurinic/apyrimidinic site cleavage assay for the identification of apurinic/apyrimidinic endonuclease inhibitors in human cells. It was used in a study to demonstrate the effect of povidone iodine ointment against skin toxicity caused by sulphur and nitrogen mustard.

Biochem/physiol Actions

Mechlorethamine hydrochloride administration reduces the tensile strength of the abdominal wounds in rats.

Safety Information

• Pictograms: GHS06,GHS08,GHS05
• Signal Word: Danger
• Hazard Statements: H300 + H310,H314,H340,H350,H360D
• Precautionary Statements: P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Oral - Carc. 1B - Eye Dam. 1 - Muta. 1B - Repr. 1B - Skin Corr. 1B
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves