187518

2,6-Dichlorobenzoyl chloride

99%

• Linear Formula: Cl₂C₆H₃COCl
• CAS Number: 4659-45-4
• Molecular Weight: 209.46
• Beilstein: 639531
• EC Number: 225-102-4
• MDL number: MFCD00000662
• UNSPSC Code: 12352100
• eCl@ss: 39050513
• PubChem Substance ID: 24851277
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 99%
• form: liquid
• refractive index: n20/D 1.560 (lit.)
• bp: 142-143 °C/21 mmHg (lit.)
• mp: 15-17 °C
• density: 1.462 g/mL at 25 °C (lit.)
• functional group: acyl chloride; chloro
• SMILES string: ClC(=O)c1c(Cl)cccc1Cl
• InChI: 1S/C7H3Cl3O/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H
• InChI key: JBLIDPPHFGWTKU-UHFFFAOYSA-N

Description

General description

2,6-Dichlorobenzoyl chloride participates in esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.

Application

2,6-Dichlorobenzoyl chloride was used:

• in substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases
• in the synthesis of 1-acyliridoles
• in enantiocontrolled total synthesis of (-)-aspicilin

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H314
• Precautionary Statements: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1
• Flash Point(F): 235.4 °F - closed cup
• Flash Point(C): 113 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves