195812

4-Amino-1-benzylpiperidine

98%

• Synonym(s): 1-(Phenylmethyl)-4-piperidinamine
• Empirical Formula (Hill Notation): C₁₂H₁₈N₂
• CAS Number: 50541-93-0
• Molecular Weight: 190.28
• Beilstein: 146038
• EC Number: 256-620-9
• MDL number: MFCD00006504
• UNSPSC Code: 12352100
• PubChem Substance ID: 24851715
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 98%
• form: liquid
• refractive index: n20/D 1.543 (lit.)
• density: 0.933 g/mL at 25 °C (lit.)
• functional group: phenyl
• SMILES string: NC1CCN(CC1)Cc2ccccc2
• InChI: 1S/C12H18N2/c13-12-6-8-14(9-7-12)10-11-4-2-1-3-5-11/h1-5,12H,6-10,13H2
• InChI key: YUBDLZGUSSWQSS-UHFFFAOYSA-N
• Gene Information: rat ... Grin2a(24409)

Description

Application

4-Amino-1-benzylpiperidine was used in the preparation of:

• butyl 4-amino-1-piperidineacetate, key intermediate required for the synthesis of butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate
• 5-alkylimino-1,2,4-thiadiazolidine-3-ones, such as 4-ethyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-methyl-1,2,4-thiadiazolidin-3-one and 4-benzyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-isopropyl-1,2,4-thiadiazolidin-3-one
• glycyrrhetinic acid derivatives

Reactant for synthesis of:
Highly selective inhibitors of p38a mitogen-activated protein kinase
Antiplasmodial compounds
Dual activity cholinesterase and Aβ-aggregation inhibitors
Muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonists
Photostable near-infrared cyanine dyes
99mTc-labeled piperidine analogues for targeting sigma receptors

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315
• Precautionary Statements: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Skin Irrit. 2
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 230.0 °F - closed cup
• Flash Point(C): 110 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves