209384

3-Methoxybenzyl chloride

97%

• Synonym(s): 3-(Chloromethyl)anisole
• Linear Formula: CH₃OC₆H₄CH₂Cl
• CAS Number: 824-98-6
• Molecular Weight: 156.61
• Beilstein: 636684
• MDL number: MFCD00000907
• UNSPSC Code: 12352100
• PubChem Substance ID: 24852566
• NACRES: NA.22

Properties

• Assay: 97%
• form: liquid
• contains: potassium carbonate as stabilizer
• refractive index: n20/D 1.544 (lit.)
• bp: 124 °C/13 mmHg (lit.)
• density: 1.078 g/mL at 25 °C (lit.); 1.078 g/mL
• functional group: chloro
• storage temp.: 2-8°C
• SMILES string: COc1cccc(CCl)c1
• InChI: 1S/C8H9ClO/c1-10-8-4-2-3-7(5-8)6-9/h2-5H,6H2,1H3
• InChI key: VGISFWWEOGVMED-UHFFFAOYSA-N

Description

Application

3-Methoxybenzyl chloride was used to alkylate 8-benzyloxy-2(1H)-quinolinone in the presence of DMF and NaH. It was also used in the synthesis of diarylmethanes via in situ organozinc-mediated, palladium-catalyzed cross-coupling between benzyl and aryl halide.

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H314
• Precautionary Statements: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1
• Flash Point(F): 213.8 °F - closed cup
• Flash Point(C): 101 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves