254738

4-Vinylbenzoic acid

97%

• Synonym(s): Styrene-4-carboxylic acid
• Linear Formula: H₂C=CHC₆H₄CO₂H
• CAS Number: 1075-49-6
• Molecular Weight: 148.16
• Beilstein: 2041130
• EC Number: 214-053-4
• MDL number: MFCD00002569
• UNSPSC Code: 12162002
• PubChem Substance ID: 24855403
• NACRES: NA.23

Properties

• Assay: 97%
• mp: 142-144 °C (lit.)
• SMILES string: OC(=O)c1ccc(C=C)cc1
• InChI: 1S/C9H8O2/c1-2-7-3-5-8(6-4-7)9(10)11/h2-6H,1H2,(H,10,11)
• InChI key: IRQWEODKXLDORP-UHFFFAOYSA-N

Description

General description

4-Vinylbenzoic acid (4-VBA), also known as styrene-4-carboxylic acid, is an aromatic compound characterized by a vinyl group attached to the para position of benzoic acid. Its vinyl group allows for free radical polymerization, facilitating the formation of various copolymers and hydrogels, making it a versatile monomer in materials science. 4-VBA exhibits good thermal stability, which is essential for applications requiring high-temperature processing and stability. Additionally, 4-VBA can also be modified to enhance its biocompatibility, making it suitable for drug delivery systems and tissue engineering.

Application

4-Vinylbenzoic acid can be used as:

• A capping agent in the preparation of polyrotaxane hydrogels. The incorporation of 4-VBA modifies and enhances the structural integrity and functionality of the resulting hydrogels, rendering them suitable for biological applications.
• A monomer in the synthesis of molecularly imprinted polymers (MIPs). The incorporation of 4-VBA contributes to improved selectivity in MIPs. The study highlights that MIPs synthesized with 4-VBA exhibit significant binding affinity towards specific biomolecules, making them effective for applications such as drug delivery and biosensing.
• A functional monomer in the synthesis of benzoic acid-modified monolithic columns. These columns are suitable for a wide range of applications, including drug analysis and environmental monitoring, where the separation of small, polar molecules is often challenging.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves