278785

Triisobutylsilane

99%

• Synonym(s): Tris(2-methylpropyl)silane
• Linear Formula: [(CH₃)₂CHCH₂]₃SiH
• CAS Number: 6485-81-0
• Molecular Weight: 200.44
• Beilstein: 1738887
• MDL number: MFCD00010340
• UNSPSC Code: 12352103
• PubChem Substance ID: 24856831
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 99%
• refractive index: n20/D 1.435 (lit.)
• bp: 204-206 °C (lit.)
• density: 0.764 g/mL at 25 °C (lit.)
• SMILES string: CC(C)C[SiH](CC(C)C)CC(C)C
• InChI: 1S/C12H28Si/c1-10(2)7-13(8-11(3)4)9-12(5)6/h10-13H,7-9H2,1-6H3
• InChI key: BORQTRQJFUNMBC-UHFFFAOYSA-N

Description

General description

Triisobutylsilane (TIBS) is a versatile organosilicon compound that finds several applications in organic synthesis. Some of its common applications include desulfurization, deprotection of the N-boc group, and radical reactions.

Application

Triisobutylsilane can be used as a reagent in combination with trifluoroacetic acid (TFA) for the deprotection of the Fmoc functional group.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 228.2 °F - closed cup
• Flash Point(C): 109 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves