375004

2,4-Thiazolidinedione

technical grade, 90%

• Synonym(s): 2,4(3H,5H)-Thiazoledione, 2,4-Dioxo-1,3-thiazolidine, 2,4-Dioxothiazolidine, 2-Hydroxy-4,5-dihydro-1,3-thiazol-4-one, Thiazole-2,4-dione, Thiazolidin-2,4-dione, Thiazolidinedione (6CI)
• Empirical Formula (Hill Notation): C₃H₃NO₂S
• CAS Number: 2295-31-0
• Molecular Weight: 117.13
• Beilstein: 110700
• EC Number: 218-941-2
• MDL number: MFCD00005478
• UNSPSC Code: 12352100
• PubChem Substance ID: 24863353
• NACRES: NA.22

Properties

• grade: technical grade
• Quality Level: 100
• Assay: 90%
• mp: 125-127 °C (lit.)
• SMILES string: O=C1CSC(=O)N1
• InChI: 1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
• InChI key: ZOBPZXTWZATXDG-UHFFFAOYSA-N

Description

General description

2,4-Thiazolidinedione is a well-known peroxisome proliferator-activated receptors (PPAR) activator. Its effect on aging process using kidneys from Fischer 344 rats has been reported. A library of conjugates of 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C catalyst. Knoevenagel condensation of various aromatic aldehydes with 2,4-thiazolidinedione in polyethylene glycol-300 has been reported.

Application

2,4-Thiazolidinedione may be used in the synthesis of sixteen 5-arylidene-2,4-thiazolidinediones, via ultrasound-promoted aldol condensation reaction. It may be used as starting material for the synthesis of drugs with antihyperglycemic activity.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves