390585

Suberohydroxamic acid

95%

• Synonym(s): N,N′-Dihydroxyoctanediamide, SBHA, Suberoyl bis-hydroxamic acid
• Linear Formula: [-(CH₂)₃CONHOH]₂
• CAS Number: 38937-66-5
• Molecular Weight: 204.22
• MDL number: MFCD00192455
• UNSPSC Code: 12352100
• PubChem Substance ID: 24864150
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 95%
• mp: 153-155 °C (lit.)
• functional group: amine
• SMILES string: ONC(=O)CCCCCCC(=O)NO
• InChI: 1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
• InChI key: IDQPVOFTURLJPT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

HDAC inhibitor

Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC₅₀ values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable