432725

2,4-Dimethoxybenzylamine

98%

• Synonym(s): (2,4-Dimethoxyphenyl)methanamine, 1-(2,4-Dimethoxyphenyl)methanamine, 2,4-Dimethoxybenzenemethanamine, 2,4-Dimethyloxybenzylamine, [(2,4-Dimethoxyphenyl)methyl]amine
• Linear Formula: (CH₃O)₂C₆H₃CH₂NH₂
• CAS Number: 20781-20-8
• Molecular Weight: 167.21
• MDL number: MFCD00052393
• UNSPSC Code: 12352100
• PubChem Substance ID: 24867094
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 98%
• refractive index: n20/D 1.549 (lit.)
• bp: 140 °C/1 mmHg (lit.)
• density: 1.113 g/mL at 25 °C (lit.)
• functional group: amine
• SMILES string: COc1ccc(CN)c(OC)c1
• InChI: 1S/C9H13NO2/c1-11-8-4-3-7(6-10)9(5-8)12-2/h3-5H,6,10H2,1-2H3
• InChI key: QOWBXWFYRXSBAS-UHFFFAOYSA-N

Description

General description

2,4-Dimethoxybenzylamine can be preprepared by reduction (NaBH₄ , BF₃.OEt₂, THF) of 2,4-dimethoxybenzonitrile.

Application

2,4-Dimethoxybenzylamine is an amine nucleophile used to investigate the 1,4- reactivity of 5-bromo-2-indene-1-one. It may be used in the following studies:

• As an ammonia equivalent in the concise synthesis of a series of 2,4,5-trisubstituted oxazoles, via a tandem Ugi/Robinson-Gabriel reaction sequence.
• Total synthesis of (-)-muraymycin (MRY) D₂ and its epimer, the antibacterial nucleoside natural product.
• Two-step synthesis of amide derivatives of uracil polyoxin C (UPOC) methyl ester using the Ugi reaction.
• Synthesis of N-hydroxythiourea.
• Synthesis of anti-HIV-1 agents.

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H314
• Precautionary Statements: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): 235.4 °F - closed cup
• Flash Point(C): 113 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves