438227

Hydroxylamine solution

50 wt. % in H₂O

• Synonym(s): HDA
• Linear Formula: NH₂OH
• CAS Number: 7803-49-8
• Molecular Weight: 33.03
• EC Number: 232-259-2
• MDL number: MFCD00044522
• UNSPSC Code: 12352116
• PubChem Substance ID: 24867438
• NACRES: NA.22

Properties

• vapor pressure: 9 mmHg ( 40 °C)
• Quality Level: 200
• form: liquid
• concentration: 50 wt. % in H₂O
• bp: >100 °C
• mp: 8 °C (46 °F)
• solubility: water: soluble
• density: 1.078 g/mL at 25 °C
• storage temp.: room temp
• SMILES string: NO
• InChI: 1S/H3NO/c1-2/h2H,1H2
• InChI key: AVXURJPOCDRRFD-UHFFFAOYSA-N

Description

General description

Hydroxylamine is a weak base that is mainly used as a reducing agent in organic reactions.

Application

Reactant for preparation of:

• Prodrug for cardiovascular agent Nω-hydroxy-L-arginine (NOHA, nitric oxide precursor)
• Hydroxyaminoguanidines as anti-cancer agents
• Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced phosphoenolpyruvate caboxykinase (PEPCK) transactivation
• Carboxamide derivatives of ofloxacin with improved antimicrobial properties
• Analogues of coumarin based TNF-α converting enzyme (TACE) inhibitors
• HIV integrase inhibitors

Safety Information

• Pictograms: GHS02,GHS08,GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H208,H290,H302,H315,H317,H318,H335,H351,H373,H400
• Precautionary Statements: P210 - P212 - P230 - P233 - P280 - P305 + P351 + P338 - P371 + P380 + P375 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Desen. Expl. 4 - Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3
• Target Organs: Blood, Respiratory system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves