465119

Baicalein

98%

• Synonym(s): 5,6,7-Trihydroxyflavone
• Empirical Formula (Hill Notation): C₁₅H₁₀O₅
• CAS Number: 491-67-8
• Molecular Weight: 270.24
• Beilstein: 272683
• MDL number: MFCD00017459
• UNSPSC Code: 12352100
• PubChem Substance ID: 24870246
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 98%
• form: solid
• mp: 256-271 °C (lit.)
• functional group: ketone; phenyl
• SMILES string: Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
• InChI key: FXNFHKRTJBSTCS-UHFFFAOYSA-N
• Gene Information: mouse ... Hexa(15211) ; rat ... Alox15(81639), Alox5(25290)

Description

General description

Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.

Application

Baicalein was used in a study to investigate the in vitro quantitative inhibition of lipoxygenase.

Biochem/physiol Actions

The flavonoid component of Nepalese and Sino-Japanese crude drugs. Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves