46920

Fmoc N-hydroxysuccinimide ester

≥98.0% (HPLC), for peptide synthesis

• Synonym(s): 9-Fluorenylmethyl N-succinimidyl carbonate, N-(9-Fluorenylmethoxycarbonyloxy)succinimide, Fmoc-OSu
• Empirical Formula (Hill Notation): C₁₉H₁₅NO₅
• CAS Number: 82911-69-1
• Molecular Weight: 337.33
• Beilstein: 3569540
• EC Number: 433-520-5
• MDL number: MFCD00010733
• UNSPSC Code: 12352108
• PubChem Substance ID: 57650882
• NACRES: NA.22

Properties

• Product Name: Fmoc N-hydroxysuccinimide ester, ≥98.0% (HPLC)
• Quality Level: 200
• Assay: ≥98.0% (HPLC)
• form: powder
• mp: 150-153 °C (lit.)
• application(s): peptide synthesis
• functional group: Fmoc; imide
• storage temp.: 2-8°C
• SMILES string: O=C(OCC1c2ccccc2-c3ccccc13)ON4C(=O)CCC4=O
• InChI: 1S/C19H15NO5/c21-17-9-10-18(22)20(17)25-19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2
• InChI key: WMSUFWLPZLCIHP-UHFFFAOYSA-N

Description

Application

Most efficient reagent for the selective preparation of N-(9-fluorenylmethoxycarbonyl) derivatives of hydroxy-amino acids in high yield. Dipeptide formation is lower than with the chloroformate, Fmoc-Cl. It has been employed in the synthesis of glycopeptides.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302 - H317 - H411
• Precautionary Statements: P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves