539112

4-Bromo-1-fluoro-2-nitrobenzene

96%

• Linear Formula: BrC₆H₃(F)NO₂
• CAS Number: 364-73-8
• Molecular Weight: 220.00
• MDL number: MFCD00129165
• UNSPSC Code: 12352100
• PubChem Substance ID: 24878380
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 96%
• refractive index: n20/D 1.575 (lit.)
• bp: 240-241 °C (lit.)
• mp: 18-19 °C (lit.)
• density: 1.786 g/mL at 25 °C (lit.)
• functional group: bromo; fluoro; nitro
• SMILES string: [O-][N+](=O)c1cc(Br)ccc1F
• InChI: 1S/C6H3BrFNO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H
• InChI key: UQEANKGXXSENNF-UHFFFAOYSA-N

Description

General description

4-Bromo-1-fluoro-2-nitrobenzene undergoes Sonogashira reaction with 2-fluoronitrobenzene to afford predominantly the bromo displacement product.

Application

4-Bromo-1-fluoro-2-nitrobenzene may be used in the synthesis of:

• 6-bromo-1H-benzo[d][1,2,3]triazol-1-ol
• 2-(4-bromo-2-nitrophenylamino)-5-methylthiophene-3-carbonitrile
• dibenzoxazepine analog, as potent sodium channel blocker
• 4-(4-bromo-2-nitrophenyl)piperazine-1-carboxylic acid tert-butylester

Used in the synthesis of anti-inflammatory agents.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves