540188

Methyl 1-hydroxy-2-naphthoate

98%

• Linear Formula: HOC₁₀H₆CO₂CH₃
• CAS Number: 948-03-8
• Molecular Weight: 202.21
• EC Number: 213-434-2
• MDL number: MFCD00043823
• UNSPSC Code: 12352100
• PubChem Substance ID: 24878446
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 98%
• mp: 76-80 °C (lit.)
• functional group: ester
• SMILES string: COC(=O)c1ccc2ccccc2c1O
• InChI: 1S/C12H10O3/c1-15-12(14)10-7-6-8-4-2-3-5-9(8)11(10)13/h2-7,13H,1H3
• InChI key: HMIBDRSTVGFJPB-UHFFFAOYSA-N

Description

General description

The asymmetric unit of the crystal of methyl 1-hydroxy-2-naphthoate contains two independent planar molecules that exhibit intra­molecular hydrogen bonds. Methyl 1-hydroxy-2-naphthoate can be prepared from 1-hydroxy-2-naphthoic acid, via esterification.

Application

Methyl 1-hydroxy-2-naphthoate may be used as a starting reagent for the synthesis of axially chiral benzimidazole derivatives.
It may also be employed in the synthesis of the following aza-mollugin derivatives:

• azamollugin
• 2-desmethyl-azamollugin
• 2,2-didesmethyl-azamollugin

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves