83060

tert-Butyl 12-amino-4,7,10-trioxadodecanoate

technical, ≥80% (T)

• Synonym(s): Amino-PEG3-tert-butyl ester, tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate
• Empirical Formula (Hill Notation): C₁₃H₂₇NO₅
• CAS Number: 252881-74-6
• Molecular Weight: 277.36
• MDL number: MFCD06201017
• UNSPSC Code: 12352200
• PubChem Substance ID: 57652942
• NACRES: NA.22

Properties

• grade: technical
• Quality Level: 100
• Assay: ≥80% (T)
• form: solid
• reaction suitability: reagent type: cross-linking reagent
• storage temp.: −20°C
• SMILES string: CC(C)(C)OC(=O)CCOCCOCCOCCN
• InChI: 1S/C13H27NO5/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h4-11,14H2,1-3H3
• InChI key: CWFSAZJIJBTKRC-UHFFFAOYSA-N

Description

Application

tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:

• Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.
• Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.
• Synthesis of polycationic adamantane-based dendrons for cell imaging.
• Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).

Other Notes

Intermediate in the synthesis of a spacer for combinatorial chemistry

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): 337.5 °F
• Flash Point(C): 169.7 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves