901572

Bromo-PEG₂-acid

≥95%

• Empirical Formula (Hill Notation): C₇H₁₃BrO₄
• CAS Number: 1807503-92-9
• Molecular Weight: 241.08
• MDL number: MFCD28122969
• UNSPSC Code: 12352101
• NACRES: NA.22

Properties

• Assay: ≥95%
• form: liquid
• reaction suitability: reagent type: linker
• functional group: bromo; carboxylic acid
• storage temp.: −20°C
• SMILES string: BrCCOCCOCCC(O)=O
• InChI key: CCEBKJLCKKPYHB-UHFFFAOYSA-N

Description

Application

Bromo-PEG₂-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG₂-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with a bromo group on one end and a carboxyl group on the other end. The compound contains two PEG units to help improve solubility.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3