902551

BocNH-PEG4-acid

• Synonym(s): 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH₂COOH
• Empirical Formula (Hill Notation): C₁₅H₂₉NO₈
• CAS Number: 876345-13-0
• Molecular Weight: 351.39
• MDL number: MFCD30528568
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• form: liquid
• reaction suitability: reaction type: Pegylations; reagent type: cross-linking reagent
• refractive index: n/D 1.4641
• density: 1.1395 g/mL
• functional group: Boc; amine; carboxylic acid
• storage temp.: −20°C
• SMILES string: OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C15H29NO8/c1-15(2,3)24-14(19)16-4-5-20-6-7-21-8-9-22-10-11-23-12-13(17)18/h4-12H2,1-3H3,(H,16,19)(H,17,18)
• InChI key: SHMYENBXRNPSOG-UHFFFAOYSA-N

Description

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Other Notes

A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable