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930741

Sigma-Aldrich

Poly(oligoethylene glycol methacrylate)

Synonym(s):

POEGMA, Poly(oligo(ethylene glycol)methacrylate)

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50 μG
RM 2,282.00

RM 2,282.00


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50 μG
RM 2,282.00

About This Item

Linear Formula:
C6H8NO2[C4H5O2(C2H4O)x]nOH
UNSPSC Code:
12352104
NACRES:
NA.21

RM 2,282.00


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form

liquid

Quality Level

mol wt

80,000-130,000

color

colorless

storage temp.

−20°C

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CLS4069P1825HS120499
feature

adjustable

feature

single-channel

feature

-

feature

Holds 16 x pipettors

manufacturer/tradename

Heathrow Scientific 120554

manufacturer/tradename

Corning

manufacturer/tradename

Drummond Scientific 4-000-101

manufacturer/tradename

Heathrow Scientific HS120499

volume × volume × volume

2-20 μL × 20-200 μL × 100-1000 μL

volume × volume × volume

-

volume × volume × volume

-

volume × volume × volume

-

General description

Poly(oligo(ethylene glycol) methacrylate) (POEGMA) is a family of polymers consisting of a hydrophobic methacrylate backbone and hydrophilic ethylene oxide (EO) side groups with highly branched architecture. The highly branched architecture with a high density of oligo EO moities enhances the solubility of the polymer in water.

Application

  • Drug delivery- enhances the stability and delivery of siRNA and eliminates PEG antigenicity
  • Biosensor coatings- provides an anti-fouling surface
  • Stimuli-responsive hydrogels for tissue engineering, drug delivery, and other biomedical applications
Poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) is a family of polymers consisting of a hydrophobic methacrylate backbone and hydrophilic ethylene oxide (EO) side groups with highly branched architecture[1] . The side chain EO segments enhance the solubility of the polymer in water [2], exhibiting many interesting properties such as non-fouling [3], stealth, anti-PEG antibodies [4] & thermo-responsive [5] behaviors.

Features and Benefits

  • Highly branched architecture and high density of oligo ethylene oxide moieties
  • Water soluble
  • Nonfouling and thermo-responsive behaviors
  • Viable alternative to PEG in biological and biomaterial applications

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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J Badet
Pathologie-biologie, 47(4), 345-351 (1999-06-18)
Angiogenin is a heparin-binding 14 kDa plasma protein with angiogenic and ribonucleolytic activity. Although its structural features have been extensively studied, an understanding of its physiological role and of how its properties are expressed continues to elude researchers. This article
D J Strydom
Cellular and molecular life sciences : CMLS, 54(8), 811-824 (1998-10-07)
The angiogenic and other biological functions of the angiogenins, members of the pancreatic RNase superfamily of proteins, are reviewed in the context of their primary and tertiary structures. The ribonucleolytic activity and interactions with the placental ribonuclease inhibitor have seen
Human angiogenin lacks specific antimicrobial activity
Avdeeva, Svetlana V, et al.
Current Microbiology, 53(6), 477-478 (2006)
E Hatzi et al.
European journal of biochemistry, 260(3), 825-832 (1999-04-02)
Human angiogenin is a plasma protein with angiogenic and ribonucleolytic activities. Angiogenin inhibited both DNA replication and proliferation of aortic smooth muscle cells. Binding of 125I-angiogenin to bovine aortic smooth muscle cells at 4 degrees C was specific, saturable, reversible

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