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Sigma-Aldrich

NanoFabTx™ - Azide Lipid Mix

for synthesis of azide-functionalized liposomes

Synonym(s):

Azide-PEG-DSPE, Cholesterol, HSPC, PEG-PE

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

Quality Level

100

storage temp.

−20°C

Application

The NanoFabTx™ Azide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of azide-functionalized liposomes, which can be used for targeting and immunotherapy applications, and small molecule encapsulation.

This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis azide-functionalized liposomes by extrusion and microfluidics are included. The synthesized azide-functionalized liposomes enables the conjugation of DBCO or alkyne-modified antibodies, proteins, aptamers, or other molecules to the liposomes surface which can be used for multi-targeting or multi-type cargo delivery to difference cell types including immune cells.

Features and Benefits

  • A ready-to-use nanoformulation lipid blend to synthesize azide-functionalized liposomes
  • Step-by-step protocols developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Optimized to make liposomes around 100 nm with low polydispersity
  • Optimized lipid blend for DBCO-modified protein or antibody conjugation
  • Optimized lipid blend for azide-functionalized liposomes for small molecule encapsulation
For microfluidic liposome synthesis of azide-functionalized liposomes, the NanoFabTx™- Azide Lipid Mix can be used with the the NanoFabTx™ Microfluidic - nano device kit (Cat.No. 911593). The NanoFabTx™ Microfluidic - nano device kit includes the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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