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ALD00613

Sigma-Aldrich

PSI2

Synonym(s):

Ψ2, 2-(Perfluorophenoxy)-1,3,2-dithiaphospholane 2-sulfide, Achiral phosphorus-sulfur Incorporation reagent

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50 MG
$428.00

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50 MG
$428.00

About This Item

Empirical Formula (Hill Notation):
C8H4F5OPS3
Molecular Weight:
338.28
UNSPSC Code:
12352005
NACRES:
NA.22

$428.00

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form

powder

Quality Level

100

mp

94-97 °C

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material

black polystyrene (square)

material

square black polystyrene

material

square black polystyrene

manufacturer/tradename

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manufacturer/tradename

Heathrow Scientific HS1423BB

manufacturer/tradename

Heathrow Scientific HS1423A

manufacturer/tradename

Heathrow Scientific HS1423B

packaging

pk of 500 ea

packaging

pk of 500 ea

packaging

pk of 500 ea

packaging

pk of 500 ea

size

small

size

medium

size

small

size

medium

feature

Anti-static

feature

Anti-static

feature

-

feature

-

L × W × H

(46 mm) × 46 mm × 8 mm

L × W × H

(85 mm) × 84 mm × 24 mm

L × W × H

(46 mm) × 46 mm × 8 mm

L × W × H

(85 mm) × 84 mm × 24 mm

Application

PSI2 is a stable and sustainably prepared P(V) reagent developed by the Baran Lab for the synthesis of phosphorodithioate oligonucleotides. The phosphorodithioate linkages afforded by PSI2 are effectively cleaved by RNAse-H while remaining stable to nucleases, and can be formed rapidly in high yield. The synthetic methodology accessed by PSI2 and other PSI reagents (see ALD00602 and ALD00604) allows at will installation of a greater diversity of linkages to DNA and other nucleotides with comparable performance to existing state-of-the-art P(III) based reagents. The resulting compounds have applications in gene-based therapeutics such as antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents

Other Notes

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    S N Tawde et al.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 8(4), 436-440 (2012-10-30)
    A 4-year-old, 37 kg, male German shepherd developed hyperthermia, tachycardia, and agitation following consumption of ground meat found in the backyard of its owner. When presented to a veterinary clinic, plasma ethylene glycol (EG) testing was positive, and the dog was
    C A Bhadkambekar et al.
    Journal of analytical toxicology, 32(9), 760-762 (2008-11-22)
    Zinc as a marker element in the viscera of suspected metal phosphide poisoning has been studied during the present work. Neutron activation analysis (NAA) has been employed to detect and quantify the concentration of zinc in the viscera/stomach portion. The
    MMWR. Morbidity and mortality weekly report, 61(16), 286-288 (2012-04-27)
    Zinc phosphide (Zn3P2) is a readily available rodenticide that, on contact with stomach acid and water, produces phosphine (PH3), a highly toxic gas. Household pets that ingest Zn3P2 often will regurgitate, releasing PH3 into the air. Veterinary hospital staff members
    Severe metabolic acidosis secondary to zinc phosphide poisoning.
    Murat Orak et al.
    JPMA. The Journal of the Pakistan Medical Association, 58(5), 289-290 (2008-07-29)
    Tanuj Kanchan et al.
    Journal of forensic and legal medicine, 15(1), 7-14 (2007-12-22)
    Poisoning is an important health hazard and one of the leading causes of morbidity and mortality worldwide. Poisoning is one of the preferred means of committing suicide among males and females in India. A five year retrospective study from January
    View All Related Papers

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