H0751

Homogentisic acid

crystalline

• Synonym(s): 2,5-Dihydroxyphenylacetic acid
• Linear Formula: (HO)₂C₆H₃CH₂CO₂H
• CAS Number: 451-13-8
• Molecular Weight: 168.15
• Beilstein: 2692860
• EC Number: 207-192-7
• MDL number: MFCD00004324
• UNSPSC Code: 12352100
• PubChem Substance ID: 57654223
• NACRES: NA.22

Properties

• form: crystalline
• Quality Level: 200
• color: off-white to tan
• mp: 150-152 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: OC(=O)Cc1cc(O)ccc1O
• InChI: 1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)
• InChI key: IGMNYECMUMZDDF-UHFFFAOYSA-N

Description

General description

Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. Alkaptonuria, a metabolic disorder, is characterized by high levels of HGA in serum and urine due to the deficiency of the enzyme homogentisic acid oxidase, which is involved in the degradation of HGA.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves