L134

Linopirdine

≥98% (HPLC)

• Synonym(s): 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one, DuP 996
• Empirical Formula (Hill Notation): C₂₆H₂₁N₃O
• CAS Number: 105431-72-9
• Molecular Weight: 391.46
• MDL number: MFCD00867216
• UNSPSC Code: 12352100
• PubChem Substance ID: 57654323
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• color: white to off-white
• solubility: DMSO: >10 mg/mL; ethanol: 240 mg/mL
• SMILES string: O=C1N(c2ccccc2)c3ccccc3C1(Cc4ccncc4)Cc5ccncc5
• InChI: 1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2
• InChI key: YEJCDKJIEMIWRQ-UHFFFAOYSA-N
• Gene Information: rat ... Kcnj1(24521)

Description

General description

Linopiridine is a class of drugs that activates the nervous system and enhances the acetylcholine (Ach) in the brain. It can be prepared by reacting oxiindole with 4-picolyl chloride hydrochloride in the presence of a KF-Al₂O₃ catalyst.

Biochem/physiol Actions

Stimulates release of acetylcholine and other neurotransmitters; cognitive enhancer.

Legal Information

Sold under exclusive license from DuPont.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves