W381101

Neohesperidin dihydrochalcone

≥96%, FG

• Synonym(s): 1-(4-((2-O-[6-Deoxy-α-L-mannopyranosyl]-β-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone, NHDC
• Empirical Formula (Hill Notation): C₂₈H₃₆O₁₅
• CAS Number: 20702-77-6
• Molecular Weight: 612.58
• FEMA Number: 3811
• EC Number: 243-978-6
• MDL number: MFCD00017711
• UNSPSC Code: 12164502
• PubChem Substance ID: 24901889
• Flavis number: 16.061
• E Number: E 959
• NACRES: NA.21
• Grade: FG; Fragrance grade; Halal; Kosher
• Biological source: synthetic
• Food allergen: no known allergens

Properties

• biological source: synthetic
• Quality Level: 300; 400
• grade: FG; Fragrance grade; Halal; Kosher
• Agency: follows IFRA guidelines
• reg. compliance: EU Regulation 1223/2009; EU Regulation 1334/2008 & 872/2012
• Assay: ≥96%
• mp: 156-158 °C (lit.)
• application(s): flavors and fragrances
• Documentation: see Safety & Documentation for available documents
• food allergen: no known allergens

Description

General description

Neohesperidin dihydrochalcone is mainly used as a sweetener and flavoring agent. It can be prepared by the hydrogenation of neohesperidin, a bitter flavonone found in citrus fruits.

Application

Neohesperidin dihydrochalcone down-regulates MyD88-dependent and -independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts.: This study explores the molecular mechanisms behind the immunomodulatory effects of Neohesperidin dihydrochalcone, revealing its potential to mitigate endotoxin-induced inflammatory responses (Xia et al., 2015).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves