700037P
Avanti
24(R/S),25-epoxycholesterol
Avanti Research™ - A Croda Brand
Synonym(s):
Cholest-5-en-3-ol, 24,25-epoxy-, (3β)-
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About This Item
Empirical Formula (Hill Notation):
C27H44O2
CAS Number:
Molecular Weight:
400.64
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 1 mg (700037P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
Application
24(R/S),25-epoxycholesterol has been used as liver X receptor ligand in breast cancer cell lines.
Biochem/physiol Actions
24(R/S),25-epoxycholesterol (24(R/S),25-EC) is a side chain substituted cholesterol. It is an effective activator of liver X receptor (LXR) transcription. 24R and 24S epimers of epoxycholesterol inhibit cholesterol synthesis from 24,25-dihydrolanosterol. The levels of 24(R/S),25-EC is elevated in gastric carcinoma and may also inhibit gastric tumor invasion. 24(R/S),25-EC regulates gastric epithelial function and also may modulates the phosphatidylinositol 3-kinase - protein kinase B (PI3K/AKT) signaling.
Packaging
5 mL Amber Glass Screw Cap Vial (700037P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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