700044P

7β-hydroxycholesterol-d7

Avanti Research^™ - A Croda Brand

• Synonym(s): cholest-5-ene-3b,7b-diol(d7)
• Empirical Formula (Hill Notation): C₂₇H₃₉O₂D₇
• CAS Number: 349553-97-5
• Molecular Weight: 409.70
• MDL number: MFCD03427682
• UNSPSC Code: 12352100
• NACRES: NA.25

Properties

• description: cholest-5-en-3β,7β-diol-d7
• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (700044P-1mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol. 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.

Application

7β-hydroxycholesterol-d7 has been used:

• as cholesterol oxidation product for mass spectroscopy analysis
• as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis
• as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry
• as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification

Biochem/physiol Actions

7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.

Packaging

5 mL Amber Glass Screw Cap Vial (700044P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids