810205P

NBD Sphingosine

omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol, powder

• Synonym(s): D-erythro-Sphingosine-N-NBD
• Empirical Formula (Hill Notation): C₂₄H₃₉N₅O₅
• CAS Number: 799268-47-6
• Molecular Weight: 477.60
• MDL number: MFCD22416765
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 250 μg (810205P-250ug); pkg of 1 × 50 μg (810205P-50ug)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 810205P
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCCNC1=CC=C([N+]([O-])=O)C2=NON=C21
• InChI key: MNFOPKRTMFDMJV-HCEDEFRUSA-N

Description

General description

Sphingosine is the most bioactive sphingoid and a constituent of cell membrane. NBD sphingosine is a derivative of sphingosine tagged with the fluorophore, 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) group.

Application

NBD Sphingosine or omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol has been used to measure sphingosine kinase 1 (SPHK1) and sphingosine kinase 2 (SPK2) activity. NBD Sphingosine may be used as a negative control to determine the binding of Atg12-Atg5 conjugate with phosphatidylethanolamine(PE)-containing liposomes and to label sphingosine kinase 1 (SphK1) to determine its role in endocytic membrane trafficking.

Biochem/physiol Actions

Sphingosine is the precursor of ceramide. It plays a major role as a selective inhibitor of protein kinase C.

Packaging

5 mL Amber Glass Screw Cap Vial (810205P-250UG)

5ML Amber Glass Screw Cap Vial (810205P-50UG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable