8.52030

Fmoc-Thr-OH

Novabiochem^®

• Synonym(s): Fmoc-Thr-OH, N-α-Fmoc-L-threonine
• Empirical Formula (Hill Notation): C₁₉H₁₉NO₅
• CAS Number: 73731-37-0
• Molecular Weight: 341.36
• MDL number: MFCD00792901
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥93.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• mp: 90-100 °C
• application(s): peptide synthesis
• functional group: hydroxyl
• storage temp.: 2-30°C
• SMILES string: N([C@@H]([C@@H](O)C)C(=O)[O-])C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C19H19NO5/c1-11(21)17(18(22)23)20-19(24)25-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,11,16-17,21H,10H2,1H3,(H,20,24)(H,22,23)/p-1/t11-,17-/m0/s1
• InChI key: OYULCCKKLJPNPU-GTNSWQLSSA-M

Description

General description

Useful derivative for the synthesis of phosphothreonine peptides by the Fmoc SPPS global phosphorylation methodology.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS


Literature references

^[1] P. M. Fischer, et al. (1991) Int. J. Peptide Protein Res., 38, 491

Linkage

Replaces: 04-12-1060

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011C)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 93.0 %
Water (K. F.): ≤ 6.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable