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916846

Sigma-Aldrich

2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid

95%

Synonym(s):

Semi-flexible linker for PROTAC® development

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100 μG
₹54,582.00

About This Item

Empirical Formula (Hill Notation):
C17H23NO4
CAS Number:
170838-26-3
Molecular Weight:
305.37
MDL number:
MFCD08460729
UNSPSC Code:
12352106

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Quality Level

100

Assay

95%

form

powder

reaction suitability

reagent type: linker

functional group

Boc
carboxylic acid

storage temp.

2-8°C

SMILES string

O=C(N(CC1)CCC1C(C=CC=C2)=C2C(O)=O)OC(C)(C)C

InChI

1S/C17H23NO4/c1-17(2,3)22-16(21)18-10-8-12(9-11-18)13-6-4-5-7-14(13)15(19)20/h4-7,12H,8-11H2,1-3H3,(H,19,20)

InChI key

NPKPUCNATSURJQ-UHFFFAOYSA-N

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technique(s)

cell culture | insect: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | insect: suitable

biological source

plant

biological source

plant

biological source

synthetic

biological source

vegetable oil

form

liquid (or semi-solid)

form

oil or semi-solid

form

liquid

form

liquid (≥0.88M based on potency, density and molecular wt.)

solubility

chloroform: soluble 50 mg/mL, clear, colorless to yellow

solubility

-

solubility

-

solubility

chloroform: soluble 0.1 mL/mL, clear, faintly yellow to yellow

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

color

white to yellow

color

yellow

color

-

color

yellow-orange

Application

2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315,H317,H319,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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