311448

Sodium periodate

ACS reagent, ≥99.8%

• Synonym(s): Sodium (meta)periodate
• Linear Formula: NaIO₄
• CAS Number: 7790-28-5
• Molecular Weight: 213.89
• EC Number: 232-197-6
• MDL number: MFCD00003534
• UNSPSC Code: 12352302
• PubChem Substance ID: 329753668
• NACRES: NA.21
• grade: ACS reagent
• form: crystalline powder

Properties

• grade: ACS reagent
• Quality Level: 200
• Assay: ≥99.8%; 99.8-100.3% dry basis (ACS specification)
• form: crystalline powder
• reaction suitability: reagent type: oxidant
• impurities: ≤0.02% other halogens (as Cl)
• pH: 3.5-5.5 (25 °C, 107 g/L)
• mp: 300 °C (dec.) (lit.)
• cation traces: Mn: ≤3 ppm
• storage temp.: room temp
• SMILES string: [Na+].[O-]I(=O)(=O)=O
• InChI: 1S/HIO4.Na/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1
• InChI key: JQWHASGSAFIOCM-UHFFFAOYSA-M

Description

General description

Sodium periodate is an inorganic salt commonly used as an oxidizing agent for various organic substrates and a co-oxidant in a few other oxidation reactions. The oxidation of sodium periodate takes place in a water medium, but an organic co-solvent is used for organic substrates that are insoluble in water.

Application

Sodium periodate can be used as an oxidizing agent:

• In the selective oxidation of sulfides to sulfoxides.
• For the oxidative cleavage of a variety of 1,2-diols to generate aldehydes or ketones.
• In the oxidation of diaryl, dialkyl, and aryl alkyl selenides to the respective selenoxides.
• In the selective alkene epoxidation and alkane hydroxylation reactions.
• In the selective oxidation of activated cellulose to obtain dialdehyde cellulose (DAC) by cleavage of the bond between C₂ – C₃ in the glucose unit.
• It can also be used as an iodinating agent for the iodination of arenes and halo compounds.

Safety Information

• Pictograms: GHS03,GHS08,GHS05,GHS09
• Signal Word: Danger
• Hazard Statements: H271,H314,H372,H410
• Precautionary Statements: P210 - P260 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1C - STOT RE 1
• Target Organs: Thyroid
• Storage Class Code: 5.1A - Strongly oxidizing hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable