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166232K

Sigma-Aldrich

MAPTRIX-C-GEFYFDLRLKGDK

Collagen Mimetic, aqueous solution

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CA$555.00

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1 PKG
CA$555.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.75

CA$555.00


Please contact Customer Service for Availability

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biological source

synthetic

sterility

Filtered sterilized solution

form

aqueous solution

mol wt

~24.1 kDa

packaging

pkg of 2.5 mg

concentration

0.5 mg/mL protein

technique(s)

cell culture | mammalian: suitable

Binding Specificity

Receptor: α2β1, α3β1, Heparin
Domain: α1 (IV) - Hep III
Binding Motif: GEFYFDLRLKGDK

shipped in

ambient

storage temp.

2-8°C

Application

MAPTrix Technology provides a true extracellular microenvironment (ECM) by presenting combinatorial peptide motifs. The ECM, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions.Currently existing technology offers simple and merely adequate environments that facilitate simple cell processes such as cellular adhesion.[1][2] The simple presentation of cell adhesion motifs is not optimal for controlling more integrated processes. Crosstalk among signaling pathways act synergistically to enhance cellular responses such as cell adhesion or proliferation.[3] A study showed that a combination of extracellular matrix derived peptides presented on a surface may enhance cell adhesion strength and focal adhesion assembly. The combinatorial presentation of ECM peptides on cell growth surfaces may also promote elevated proliferation rates of primary or stem cells.[4][5][6]

Features and Benefits

  • Biochemically-defined, animal-free cell culture surfaces designed to enhance cell performance
  • MAPTrix produces a uniform ECM surface that provides a highly controlled 2D extracellular microenvironment for cell cultures and related applications
  • Adhesion properties of the mussel adhesive protein makes the coating reproducible & reliable

Legal Information

MAPTrix is a trademark of Kollodis Biosciences

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Sheng-Wei Luo et al.
    Fish & shellfish immunology, 89, 486-497 (2019-04-14)
    CD59, a multifunctional glycoprotein, not only plays a regulatory role in complement cascades, but also participates in modulation of teleostean immunity. In this study, full length sequence of EcCD59 was obtained, comprising a 5'UTR of 163 bp, an ORF of
    Yang Yie Sio et al.
    Scientific reports, 10(1), 715-715 (2020-01-22)
    Post-glycosylphosphatidylinositol (GPI) attachment to proteins 3, also known as PGAP3 or PERLD1 (PER1-like domain-containing protein 1), participates in the lipid remodeling process of glycosylphosphatidylinositol (GPI) anchor proteins during post-translational modification. Functional defect in PERLD1 was previously hypothesized to influence this
    Diego Martínez-López et al.
    Journal of the American College of Cardiology, 75(16), 1926-1941 (2020-04-25)
    The mechanisms underlying early atherosclerotic plaque formation are not completely understood. Moreover, plasma biomarkers of subclinical atherosclerosis are lacking. The purpose of this study was to analyze the temporal and topologically resolved protein changes taking place in human aortas with

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