A7400

D-2-Aminoadipic acid

• Synonym(s): (R)-2-Aminohexanedioic acid, D-Homoglutamic acid
• Linear Formula: HO₂C(CH₂)₃CH(NH₂)CO₂H
• CAS Number: 7620-28-2
• Molecular Weight: 161.16
• Beilstein: 1724347
• MDL number: MFCD00063118
• UNSPSC Code: 12352106
• PubChem Substance ID: 24891125
• NACRES: NA.32

Properties

• form: powder
• Quality Level: 200
• mp: 208-210 °C (lit.)
• SMILES string: N[C@H](CCCC(O)=O)C(O)=O
• InChI: 1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m1/s1
• InChI key: OYIFNHCXNCRBQI-SCSAIBSYSA-N
• Gene Information: rat ... Grin2a(24409), Grm1(24414), Grm2(24415), Grm6(24419)

Description

Application

D-2-Aminoadipic acid has been used as an inhibitor of glutamine synthetase in spontaneously immortalized human cell line MIO-M1.

Biochem/physiol Actions

D-2-Aminoadipic acid is a glutamate analog. It acts as an inhibitor of glutamate synthetase. D-2-Aminoadipic acid exhibits gliotoxicity towards mitotic astrocytes.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves