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About This Item
Empirical Formula (Hill Notation):
C24H34N4·HCl
CAS Number:
Molecular Weight:
415.01
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Product Name
Antalarmin hydrochloride, ≥98% (HPLC), solid
Quality Level
Assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
InChI
1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
InChI key
CGDGXEDXEXACKQ-UHFFFAOYSA-N
Application
Antalarmin hydrochloride has been used:
- to study its effect on stress-induced tryptophan hydroxylase 2 activity
- to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation
- to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression
Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.
Biochem/physiol Actions
Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.
Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.
Features and Benefits
This compound is featured on the Corticotropin-Releasing Factor Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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