B3306

Bisindolylmaleimide IV

≥98% (TLC), solid

• Synonym(s): Ro 31-6233
• Empirical Formula (Hill Notation): C₂₀H₁₃N₃O₂
• CAS Number: 119139-23-0
• Molecular Weight: 327.34
• MDL number: MFCD00236432
• UNSPSC Code: 12352111
• PubChem Substance ID: 24891709
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥98% (TLC)
• form: solid
• color: dark red
• solubility: DMSO: soluble; methanol: soluble
• storage temp.: −20°C
• SMILES string: O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c4c[nH]c5ccccc45
• InChI: 1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
• InChI key: DQYBRTASHMYDJG-UHFFFAOYSA-N
• Gene Information: human ... CDK2(1017), EGFR(1956) ; rat ... Prkca(24680)

Description

Biochem/physiol Actions

Bisindolylmaleimides (BIM) comprises a group of 11 compounds from BIM-I to BIM-XI. BIMs act as an inhibitor of protein kinase C (PKC). They are derived from staurosporine. BIM IX due to its proapoptotic functionality could be useful in targeting tumor proliferation.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves