B8684

Bambuterol hydrochloride

>98% (HPLC), powder

• Synonym(s): Dimethylcarbmic acid 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene ester
• Linear Formula: C₁₈H₂₉N₃O₅ · HCl
• CAS Number: 81732-46-9
• Molecular Weight: 403.90
• MDL number: MFCD03427293
• UNSPSC Code: 12352200
• PubChem Substance ID: 329773137
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: >98% (HPLC)
• form: powder
• storage condition: desiccated
• color: off-white
• solubility: H₂O: soluble ~33 mg/mL
• originator: AstraZeneca
• SMILES string: Cl.CN(C)C(=O)Oc1cc(OC(=O)N(C)C)cc(c1)C(O)CNC(C)(C)C
• InChI: 1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7;/h8-10,15,19,22H,11H2,1-7H3;1H
• InChI key: LBARATORRVNNQM-UHFFFAOYSA-N

Description

General description

Bambuterol is present in various tissues, like , intestine, lungs, liver and heart. It is also found in serum.

Application

Bambuterol hydrochloride has been used as a β2-adrenergic receptor (β2-AR) agonist to study its effects on graft versus host disease (GVHD) while preserving the graft-versus-tumor (GvT) effect. It has also been used in the preparation of bambuterol-poly vinyl chloride (Bb-PVC) membrane sensors for the determination of bambuterol in the pharmaceutical dosage form.

Biochem/physiol Actions

β-adrenoceptor agonist; bronchodilator; anti-asthmatic; terbutaline prodrug

Bambuterol hydrochloride is used for prophylaxis and also to treat chronic bronchitis and chronic asthma in pediatrics.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves